TYPE 2 DIABETES MELLITUS
It is very difficult to describe the patho-
physiology of T2DM for 2 reasons. First, our
understanding of this important disease is
changing almost daily as rescarch progresses.
Second, T2DM is not a single disease but is a
group of diseases, ic, a syndrome with differ
ent genetics and pathophysiology but similar
symptoms and outcome
In simplified terms,
T2DM is a combination of insulin resistance
and insulin deficiency. There is an argument
as to which come first, the insulin resistance
or the insulin deficiency, and how much of
each is genetic and how much is environmen
tal. Much research is being done in these ar
eas and the final answers are not yet in. We