abstract
We investigated the effect of mixing soy protein isolate and pomegranate juice (PJ) on the bioavailability
and metabolism of ellagitannins (ETs) in healthy volunteers. Eighteen healthy volunteers consumed PJ
alone or PJ premixed with soy protein isolate (PJSP). The concentration of plasma ellagic acid (EA) and
urine urolithins was measured. There was no significant difference in plasma EA over a 6-h period
between the two interventions. While the maximum concentration of plasma EA after PJSP consumption
was slightly but significantly lower than after PJ consumption, EA remained in the plasma longer with an
elimination half-life t1/2E at 1.36 ± 0.59 versus 1.06 ± 0.47 h for PJSP and PJ consumption, respectively.
Urinary urolithin A, B and C was not significantly different between the two interventions. In conclusion,
premixing soy protein isolate and PJ did not affect the bioavailability or the metabolism of pomegranate
ETs in healthy volunteers.