Endothelial cell (EC) oxidative stress can lead to vascular dysfunction which is an underlying
event in the development of cardiovascular disease (CVD). The lack of a potent and bioavailable antioxidant enzyme is a major challenge in studies on antioxidant therapy. The objective of this study is to determine whether copper/zinc superoxide dismutase (CuZnSOD or SOD1) after nanoformulation(nanoSOD) can effectively reduce EC oxidative stress and/or vascular inflammation in obesity. Methods.