Temperature usually played important role in extraction especially for sensitive natural compound. Previously, heating procedure to the level of temperature at 175oC showed the degradation of Monacolin K and also increased the proportion of Citrinin. However, heating procedure at temperature of below 140oC did not give significant effect for Monacolin K degradation. Condition temperature of 65oC and 30% of ethanol solution had been determined as basal condition for MFR extraction. Due to level of Citrinin decreased significantly by treatment of dry heat at 65oC for one hour10. The influence of lower temperature but longer time of extraction can be seen in Table 1. Temperature control strategy showed that extraction by use of RT and two hours contact time almost gave similar M/C ratio with extraction under heat of 65oC, 1 hour contact time with M/C ratio of 3.0. However, by use of heat at temperature of 60oC, the yield of Monacolin K increased about two fold greater than extraction in RT. Moreover, by use of 60oC degree, 110 rpm and 2 hours extraction, the ratio of M/C reached value of 3.7, which in this experiment was the best ratio of M/C. By exposure above, temperature of 60oC degree, 110 rpm, and 2 hours extraction with 95% v/v ethanolic solution gave a better condition for Monacolin K extraction from MFR