Because oral SAMe may cause nausea, a incremental regimen has been
suggested, with a starting dose of 200 mg twice daily for the first day, which is
increased to 400 mg twice daily on day 3, then to 400 mg three times daily on day 10,
and finally to the full dose of 400 mg four times daily [102]. Little research has been
done using SAMe to treat severe depression, so it is unknown whether SAMe would
have the same benefits as seen in mild-to-moderate depression.
Because oral SAMe may cause nausea, a incremental regimen has beensuggested, with a starting dose of 200 mg twice daily for the first day, which isincreased to 400 mg twice daily on day 3, then to 400 mg three times daily on day 10,and finally to the full dose of 400 mg four times daily [102]. Little research has beendone using SAMe to treat severe depression, so it is unknown whether SAMe wouldhave the same benefits as seen in mild-to-moderate depression.
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