Flavonoids are usually stored in the vacuoles of the cell; therefore, solvent molecule must be able to penetrate the cell walls to get to the compounds of interest.
Flavonoids glycosides are more water soluble and thus require the use of relatively polar solvent (De la rosa et al., 2010).
Acetone interacts with the flavonoids probably through noncovalent interactions and promotes a rapid diffusion into the solution (Luque de Castro and Tena, 1996).
The optimal extraction yield may be fulfilled when the polarity of the fluid and its flavonoids are coincident