Vascular Endothelial Growth Factor Inhibitors
Vascular endothelial growth factor inhibitor bevacizumab
in combination with paclitaxel or docetaxel improves progression-
free survival over chemotherapy alone in first-line
treatment of metastatic breast cancer. Bevacizumab plus
capecitabine shows clinical activity in first-line therapy of
metastatic breast cancer but has not been compared to
bevacizumab and taxanes. The toxicities of bevacizumab
plus chemotherapy are the same as expected side effects of
the agents when used separately, including diarrhea, HFS,
infections, asthenia, hypertension, proteinuria, bleeding, and
thrombotic events.