Premixed insulin analogues can be administered after meals (103–105) and may be associated with better control than basal insulins, but at the expense of more hypoglycemia and greater weight gain (106).
Basal-bolus regimens may be associated with greater improvements in glycemic control, health status and mood than twice-daily injections of long-acting insulin (107), although premixed insulin analogues can result in equivalent glycemic control to basal-bolus regimens (108).