Even though current scientific evidence regarding Spirulina supplementation for BW is unsatisfactory [1], our findings revealed substantial BW loss (-8.1%) accompanied by a significant reduction of HOMA-IR index (-19.6%) following Spirulina supplementation among the 15 participants. The discrepancy between our BW findings and previous studies [1] might be due to the higher dose and longer period of administration (6 g/day for six months instead of 1g/day for 3 months). However, this BW loss is remarkable considering that a moderate BW loss (5-10% of baseline BW) has a beneficial effect on cardiovascular risk factors, such as diabetes mellitus type 2, hypertension and hyperlipidemia [48,49]. Moreover, a gradual BW loss through improved diet and increased physical activity is the main guideline for the management of NAFLD [50], the cornerstone therapy of NAFLD, improving liver enzymes, insulin sensitivity, reducing inflammation and liver histology [6,51-56]. The BW loss could be explained mainly by the low fat and low carbohydrates content of Spirulina supplementation which is far lower than almost all other protein sources [1]. Research has demonstrated that BW loss with a low-fat diet reduces IR and cholesterol synthesis, and modifies fat liver in overweight non-diabetic subjects [40,57].