Essential HTN Initially 12.5 mg once daily for 1st 2 days. Maintenance: 25 mg once daily. If necessary, may increase at intervals of 2 wk to a total daily dose of 50 mg given once daily or in divided doses (twice daily). CHD Initially 12.5 mg twice daily for 1st 2 days. Maintenance: 25 mg twice daily. May increase at intervals of 2 wk to a total daily dose of 100 mg given in divided doses (twice daily). Elderly Max: 50 mg given in divided doses (twice daily). Treatment of symptomatic CHF Initially 3.125 mg twice daily for 2 wk. May increase at intervals of 2 wk to 6.25 mg twice daily, followed by 12.5 mg twice daily & thereafter 25 mg twice daily. Patient >85 kg Max: 50 mg twice daily, 2 wk, recommence at 3.125 mg twice daily & titrate dose accordingly. Left ventricular dysfunction following acute MI Initially 6.25 mg twice daily, may increase to 12.5 mg twice daily after 3-10 days & twice daily may be used &/or the rate of uptitration may be slower.