Next to epidemiological evidence, literature provides a profusion of data reporting that increased n-3 PUFA consumption in intervention studies may alleviate metabolic and cardiovascular risk. Thus, consistent with the inverse correlation found between fish and fish oil consumption and biomarkers of inflammation (TNFα, IL6, CRP) in many populations (healthy adults -[40, 57]; patients with insulin resistance [58]; coronary heart disease [59]; or the MetS [44, 60]), dietary enrichment in n-3 ALA and in EPA/DHA reduced low grade inflammation in at-risk populations [61–64].