By engineering antibacterial enzymes, Dartmouth investigators led by Karl Griswold, PhD are using novel strategies to target the prevalent drug-resistant bacterium Staphylococcus aureus. Recent papers in FEMS Microbiology Letters and Applied Microbiology and Biotechnology describe their findings from a genome mining effort seeking novel antibacterial agents. A third paper published in ACS Chemical Biology examines redesigned versions of human lysozyme, a broad-spectrum antibacterial enzyme.