INTRODUCTION
Herbal medicines play an important role in clinical
cancer therapy and have been widely accepted as potential
high quality pools in drug screening around the world, owing
to their unmatched chemical diversity and less side-effect.
Recently there have been a significant increase in the
exploitation of herbal medicine in both crude and prepared
forms, and herbal remedies are perceived as being natural
and safe. Berberine (see Fig. 1), is an isoquinoline plant alkaloid,
isolated from the Golden seal, Hvdrastis canadensis
L., a member of the family Ranuncufaceae; it also
occurs in many other plants including the Berberineeris