The Lactobacillus pentosus สายพันธุ์ TUA4337L in the present
การประดิษฐ์ can be used in a single form or a combination of two or more
kinds of forms so long as the strain has ความสามารถการเพิ่มจำนวน in the ทางเดินลำไส้. Although a total content in the composition of the การประดิษฐ์นี้ is not particularly limited, the total content is usually from 0.00001 to
25 99.9% (g/g), and especially ทททคือตั้งแต่ 0.0001% to 50% (g/g) or so.
Alternatively, the number of bacterial cells is ทททคือ within the range of from 1.0 x 102 to 1.0 x 1012 cells/g, and ทททกว่า คือ within the range of from 1.0 x 106 to 1.0 x 1012 cells/g. The above "cells/g" can be expressed in viable bacteria as "CFU/g." The lactic acid bacteria of the
5 การประดิษฐ์นี้ may be used in combination with a strain having an
action other than the action of proliferating in the ทางเดินลำไส้.
[0026] The composition of the การประดิษฐ์นี้ can contain carriers, basal
agents, and/or additives และที่คล้ายกัน which are ordinarily used in the food field, pharmaceutical formulation fields และที่คล้ายกัน within the range that
10 would not impair the effects of the การประดิษฐ์นี้, so long as the
composition contains a Lactobacillus pentosus สายพันธุ์ TUA4337L having ความสามารถการเพิ่มจำนวน in the ทางเดินลำไส้. Concretely, the composition includes various ingredients such as known sweeteners, acidifiers, and vitamins, and other agents such as excipients, binders, disintegrants,
15 lubricants, correctives, dissolution aids, suspensions, coating agents, and
stabilizers.
[0027] In addition, the composition of the การประดิษฐ์นี้ can optionally
contain one or more kinds of known components such as cosmetic
ingredients, and agents for preventing or ameliorating lifestyle-related
20 diseases, in order to add other useful actions.
[0028] The form of the composition of the การประดิษฐ์นี้ is not
particularly limited so long as the composition is in the form in which
Lactobacillus pentosus สายพันธุ์ TUA4337L having ความสามารถการเพิ่มจำนวน in
the ทางเดินลำไส้ can be ถูกกลืนกิน in the body, and the form is exemplified
25 by beverages or food containing the strain, from the viewpoint of
exhibiting the effects of the strain, tablet forms ingestible as supplements, และที่คล้ายกัน, from the viewpoint of conveniently ingesting the composition. Concrete examples include, for example, various forms such as tablets,
capsules, health-care drinks, seasonings, processed foods, desserts, and
5 confectionaries. Among these forms, those provided as fermented foods
are preferred. The fermented food is a generic name of food fermented with vegetable lactic acid bacteria, and beverages are included therein.
Although the kinds of the fermented food are not particularly limited, the fermented food includes, for example, fermented milks, lactic acid bacteria
10 beverages, fermented soy-milks, those obtained by fermenting fruits and
vegetables, such as pickled vegetables, kimchee, wines, soybean paste
(miso), and soy sauce; fermented fruit juice yogurt in which fruit juices,
vegetable juices และที่คล้ายกัน are fermented.
[0029] Here, the beverage or food in which the lactic acid bacteria of the
15 การประดิษฐ์นี้ is blended, in other words, the beverage or food
containing a Lactobacillus pentosus สายพันธุ์ TUA4337L having ความสามารถการเพิ่มจำนวน in the ทางเดินลำไส้, when ถูกกลืนกิน, exhibits a high action of
การขัดขวาง fat absorption, as compared to a case where lactic acid bacteria not having ความสามารถการเพิ่มจำนวน in the ทางเดินลำไส้ are ถูกกลืนกิน, and its
20 action continues; therefore, it is considered that as a food with health
claims or healthy food having continuous action of การขัดขวาง fat absorption, it is possible to provide an indication that such beverage or food is usable in การขัดขวาง weight gains or reducing weight, or usable in preventing
obesity or ameliorating obesity, or further usable in dieting . The food
25 with health claims as used herein means a food with health claims
ordained by the Ministry of Health, Labour and Welfare, which includes food with nutritional functional claims and food for specified heath use, and the food with health claims or healthy food may be any one of foods and beverages.
5 [0030] The composition of the การประดิษฐ์นี้ can be prepared in
accordance with a known method in the food field, the pharmaceutical
formulation field และที่คล้ายกัน, depending upon the fauns thereof
[0031] The composition of the การประดิษฐ์นี้ is properly set and not in a
certain level depending upon its form, the purposes of ingestion, and age,
10 body weight and symptoms of the subjects intended to ingest the
composition, and, for example, it is preferable that the composition is
orally ถูกกลืนกิน in an ปริมาณ, in terms of the ปริมาณ of lactic acid bacteria, of 1.0 x 106 cells or more/kg body weight per day, in a single dose to
several divided doses. In addition, the ปริมาณ of the bacterial cells
15 ถูกกลืนกิน in a day is, on a dry basis, ทททคือตั้งแต่ 0.00001 to 1 g, more
ทททคือตั้งแต่ 0.0001 to 0.2 g, and ทททกว่า นั้นคือ คือตั้งแต่ 0.0003 to
0.002 g, per about 50 kg body weight of one adult. For example, since the lactic acid bacteria of the การประดิษฐ์นี้ have the property of การขัดขวาง fat absorption, and have ความสามารถการเพิ่มจำนวน in the ทางเดินลำไส้, the
20 composition of the การประดิษฐ์นี้ may be ถูกกลืนกิน together with a high-
fat diet, or before a high-fat diet, in an ปริมาณ so that the ปริมาณ of lactic acid bacteria would be within the above range. The composition may be ถูกกลืนกิน once a day at breakfast, from the viewpoint of continuously
exhibiting the action of การขัดขวาง fat absorption. The "ถูกกลืนกิน" as used
25 herein means "ingestion" and/or "การให้."
[0032] The subjects intended to ingest the composition as used herein are
ทททคือ human in need of action of การขัดขวาง fat absorption, and may be pet animals และที่คล้ายกัน.
[0033] Thus, by ingesting the composition of the การประดิษฐ์นี้, the fat
5 absorption from the ทางเดินลำไส้ can be blocked. Therefore, the present
การประดิษฐ์ also provides a fat absorption การขัดขวาง agent ซึ่งประกอบรวมด้วย
Lactobacillus pentosus having ความสามารถการเพิ่มจำนวน in the ทางเดินลำไส้,
for การขัดขวาง absorption of a fat derived from diet from the ทางเดินลำไส้.
[0034] In addition, the การประดิษฐ์นี้ provides a method for การขัดขวาง fat
10 absorption, characterized in that the method ประกอบรวมด้วย using a
composition containing the above Lactobacillus pentosus TUA4337L
strain in an effective ปริมาณ in an individual in need of การขัดขวาง fat
absorption.
[0035] The individual in need of การขัดขวาง fat absorption is not particularly
15 limited so long as the individual is an individual with a disease which is
found to have some therapeutic effects by การขัดขวาง fat absorption. The
individual is exemplified by, for example, an individual having obesity, or a disease such as diabetes, hyperlipemia, hypertension, or arteriosclerosis caused by obesity. In addition, for the purpose of preventing or
20 ameliorating the above disease, the above individual also includes an
individual who is concerned about body weight, an individual who is
concerned about a blood sugar level, an individual who is concerned about
blood pressure, และที่คล้ายกัน.
[0036] The effective ปริมาณ refers to an ปริมาณ that blocks fat absorption
25 when the สายพันธุ์ TUA4337Led is ให้ to the above individual, as
compared to an individual without การให้. The concrete effective ปริมาณ is properly set and is not certain depending upon the dosage forms, the methods of การให้, the purposes of use, and age, body weight, symptoms และที่คล้ายกัน of individuals. Here, the การให้ is intended
5 to embrace all the embodiments of การให้, ingestion, internal
medication, and drinking.