paddy field. As a result, rice field have a lot of damage. Farmers necessary will use toxic to kill golden apple snail in rice field. Affect causing toxic to water and aquatic animal. So the farmers aware of the risks of toxic. We would test the toxicity of golden apple snail with Siridhornae fairy shrimp and Thai fairy shrimp. We use Abamectin and Nicrosamide so different concentration to test with them, Each set contains 4 repeated experiment for 24 hour. From the result with toxic 2 type, in test we found acute toxicity. Toxin by Abamectin with Siridhornae fairy shrimp have LC50 at 6 12 18 and 24 hours, values 0.1375 0.0792 0.0639 and 0.0406 micrograms per liter respectively. Toxin by Abamectin with Thai fairy shrimp have LC50 at 6 12 18 and 24 hours, values 0.4431 0.1122 0.0636 and 0.0477 micrograms per liter respectively. Toxin by Nicrosamide with Siridhornae fairy shrimp have LC50 at 6 12 18 and 24 hours, values .0721 0.0497 0.0359 and 0.0273 milligrams per liter respectively. Toxin by Nicrosamide with Thai fairy shrimp have LC50 at 6 12 18 and 24 hours, values 0.0556 0.0419 0.0242 and 0.0174 millirams per liter respectively. As a result indicate that Abamectin toxicity with both fairy shrimps more than Nicrosamide. As a result this case indicate area of Abamectin and Nicrosamide has been affect with aquatic animal.