GSSG liposomes reported here provide the first method that delivers GSSG into cells. since the method delivers only GSSG into cells, it avoid any complication caused by other indirect way to increase intracellular GSSG such as the use of GR inhibitor. the method provides an unambiguous tool and dysfunction. the simple procedure for preparation and storage stability of the dry GSSG liposomes provides convenience and also makes the product commercialization possible.