Often the patient with hemoglobin H is asymptomatic and
is unprepared for the acute complications that occur during
infection, pregnancy, and drug exposure. In particular, these
include hemolytic and aplastic anemic episodes. Folic acid
supplements and avoidance of oxidative compounds and
medications are recommended. In mild cases, biannual visits are
adequate. In more severe cases, more frequent visits are indicated.
At routine visits, growth, development, facial bone deformity,
dental status, and hepatosplenomegaly should be monitored.
Routine monitoring of hemoglobin levels is required.