3.7. Effect of mulberry on Aβdeposition is correlated with
cognitive performance
The hippocampus, which is an area of the brain that is crucial for
learning and memory, has also been established as a common location
of pathologic Aβaccumulation. In this study, we used Western blot
assays to examine whether treatment with ME decreased the
accumulation of Aβtypically occurring with age. As shown inFig. 6,
a significantly (Pb.05) higher amount of Aβwas observed in the brains
of Group II mice than in Group I, and supplementation with ME was
able to significantly reduce Aβaccumulation. Furthermore, regression
analysis reported significant negative correlation between the
cognitive performance and the expression of Aβ (Fig. 7). Aβ
negatively significantly correlated with active avoidance response
(r=−0.419, Pb.05) and passive avoidance response (r=−0.223,
Pb.05) of tested mice. These data suggested that the observed
improvement in age-related cognitive decline secondary to consumption of ME might be through a reduction in Aβlevels
3.7. Effect of mulberry on Aβdeposition is correlated withcognitive performanceThe hippocampus, which is an area of the brain that is crucial forlearning and memory, has also been established as a common locationof pathologic Aβaccumulation. In this study, we used Western blotassays to examine whether treatment with ME decreased theaccumulation of Aβtypically occurring with age. As shown inFig. 6,a significantly (Pb.05) higher amount of Aβwas observed in the brainsof Group II mice than in Group I, and supplementation with ME wasable to significantly reduce Aβaccumulation. Furthermore, regressionanalysis reported significant negative correlation between thecognitive performance and the expression of Aβ (Fig. 7). Aβnegatively significantly correlated with active avoidance response(r=−0.419, Pb.05) and passive avoidance response (r=−0.223,Pb.05) of tested mice. These data suggested that the observedimprovement in age-related cognitive decline secondary to consumption of ME might be through a reduction in Aβlevels
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