I first got attached to Spider-man's villans. Doc Ock, Vulture, Venom, Green Goblin etc. They are my favorite in all comics. They are all so unique and differen't from one another and by the time you do get a villan that is similar to one another (such as Green Goblin and Hobgoblin, or Venom or Carnage) they both come off as cool. Another reason is just the uphill climb that Spider-man is always taking. He never really seemed like a superhero who had everything he ever wanted. I used to enjoy the fact that he was surprisingly independant (until know with the Avengers). He always took matters into his own hands. He will always be my favorite