Polycaprolactone (PCL) (Fig. 1) is a semi-crystalline polymer,
rather hydrophobic, with a high molecular weight. It may be used
in diffusion-controlled delivery systems. The main mode of degradation
for caprolactone polymers is hydrolysis. This degradation
proceeds first by diffusion of water into the material, followed by
random hydrolysis fragmentation of the material, and finally more
extensive hydrolysis accompanied by phagocytosis, diffusion, and
metabolism. The hydrolysis is affected by the size, hydrophilicity,
and crystallinity of the polymer and the pH and temperature of the
environment [34].
Polycaprolactone (PCL) (Fig. 1) is a semi-crystalline polymer,rather hydrophobic, with a high molecular weight. It may be usedin diffusion-controlled delivery systems. The main mode of degradationfor caprolactone polymers is hydrolysis. This degradationproceeds first by diffusion of water into the material, followed byrandom hydrolysis fragmentation of the material, and finally moreextensive hydrolysis accompanied by phagocytosis, diffusion, andmetabolism. The hydrolysis is affected by the size, hydrophilicity,and crystallinity of the polymer and the pH and temperature of theenvironment [34].
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