In A. aegypti the maximum intensity of vg synthesis is attaincd 27 hours after the blood meal. The vg synthesis then declines rapidly due to the action of lysosmes. Endoplasmic reticulum and Golgi complexes are degraded in two steps, that consist of the formation of a prelysosome and its fusion with a primary or secondary lysosome. the mature vg-containing secrotory granules, on the other hand, fuse with lysosomes directly.