The pigment pheomelanin gives red hair its distinctive color. Red hair has far more of the pigment pheomelanin than it has of the dark pigment eumelanin.
The genetics of red hair, discovered in 1997, appear to be associated with the melanocortin-1 receptor (MC1R), which is found on chromosome 16. Red hair is associated with fair skin color because low concentrations of eumelanin throughout the body of those with red hair caused by a MC1R mutation can cause both. The lower melanin concentration in skin confers the advantage that a sufficient concentration of important Vitamin D can be produced under low light conditions. However, when UV-radiation is strong (as in regions close to the equator) the lower concentration of melanin leads to several medical disadvantages, such as a higher risk of skin cancer.
The MC1R recessive variant gene that gives people red hair and non-tanning skin is also associated with freckles, though it is not uncommon to see a redhead without freckles.[why?] Eighty percent of redheads have an MC1R gene variant,[2] and the prevalence of these alleles is highest in Scotland and Ireland.
Red hair can originate from several changes on the MC1R-gene. If one of these changes is present on both chromosomes then the respective individual is likely to have red hair. This type of inheritance is described as an autosomal recessive mode of inheritance. Even if both parents do not have red hair themselves, both can be carriers for the gene and have a redheaded child.
Genetic studies of dizygotic (fraternal) twins indicate that the MC1R gene is not solely responsible for the red hair phenotype; unidentified modifier genes exist, making variance in the MC1R gene necessary, but not always sufficient, for red hair production.[25]
The pigment pheomelanin gives red hair its distinctive color. Red hair has far more of the pigment pheomelanin than it has of the dark pigment eumelanin.The genetics of red hair, discovered in 1997, appear to be associated with the melanocortin-1 receptor (MC1R), which is found on chromosome 16. Red hair is associated with fair skin color because low concentrations of eumelanin throughout the body of those with red hair caused by a MC1R mutation can cause both. The lower melanin concentration in skin confers the advantage that a sufficient concentration of important Vitamin D can be produced under low light conditions. However, when UV-radiation is strong (as in regions close to the equator) the lower concentration of melanin leads to several medical disadvantages, such as a higher risk of skin cancer.The MC1R recessive variant gene that gives people red hair and non-tanning skin is also associated with freckles, though it is not uncommon to see a redhead without freckles.[why?] Eighty percent of redheads have an MC1R gene variant,[2] and the prevalence of these alleles is highest in Scotland and Ireland.Red hair can originate from several changes on the MC1R-gene. If one of these changes is present on both chromosomes then the respective individual is likely to have red hair. This type of inheritance is described as an autosomal recessive mode of inheritance. Even if both parents do not have red hair themselves, both can be carriers for the gene and have a redheaded child.Genetic studies of dizygotic (fraternal) twins indicate that the MC1R gene is not solely responsible for the red hair phenotype; unidentified modifier genes exist, making variance in the MC1R gene necessary, but not always sufficient, for red hair production.[25]
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