Esphogeal tissue
In the carcinogen-treated group, 9 of 10 rats (90%) developed squamous dysplasia of variable degree (mild to severe) and extent (involving long segments of epithelium). 1 of 10 rats (10%) developed squamous cell carcinoma involving a longer segment of esophagus. However, in the carcinogen plus MRN-100-treated group, a fewer number of rats, 4 of 10 (40%) developed squamous dysplasia, and the dysplasia was of lesser degree and extent than those treated with the carcinogen alone. Although 1 of 10 rats (10%) also developed squamous cell carcinoma, the extent of involvement was lesser than in the carcinogen group (Table 2).
Esphogeal tissue
In the carcinogen-treated group, 9 of 10 rats (90%) developed squamous dysplasia of variable degree (mild to severe) and extent (involving long segments of epithelium). 1 of 10 rats (10%) developed squamous cell carcinoma involving a longer segment of esophagus. However, in the carcinogen plus MRN-100-treated group, a fewer number of rats, 4 of 10 (40%) developed squamous dysplasia, and the dysplasia was of lesser degree and extent than those treated with the carcinogen alone. Although 1 of 10 rats (10%) also developed squamous cell carcinoma, the extent of involvement was lesser than in the carcinogen group (Table 2).
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