Stress disorder among students is a major concern in tertiary education. This study aimed to determine the predominance source of stress among health sciences students in a government university in Malaysia by using validated Medical Student Stressor Questionnaire (MSSQ). Methodology: The MSSQ was distributed to 248 health science students. The items of MSSQ represent 40 events that reported to being possible sources of stress. Result and discussion: The MSSQ showed satisfactory level of psychometric property in the health science students. The main source of stress was the academic related stressor Conclusion: Academic requirement is the major stressor for the students. This finding is consistent with the literature and appropriate measures should be sought to prevent its unwanted consequences