3.6. Effect of mulberry on Nrf2 translocation
The transcription factor Nrf2 plays an important role in modulating responses to oxidative stress. Fig. 5shows the effects of ME on
Nrf2 levels in the liver of SAM mice. In comparison to Group I,
significantly (Pb.05) lower nuclear Nrf2 was observed in Group II;
however, the nuclear Nrf2 level was increased upon treatment with
mulberry or BE. These data suggested that the consumption of
mulberry or BE promoted Nrf2 expression and transcription factor
translocation to the nucleus, thus increasing the expression of
antioxidant enzymes.