Lung cancer is the major cause of cancer-related mortality throughout the world. The major type of lung cancer found in patients is non-small cell lung cancer(NSCLC), which has been classified as the malignant tumor with metastasis at advanced stage by the time of diagnosis. Metastasis in patients with lung cancer has become an important hallmark of difficulty in treatment and poor prognosis because metastatic tumors cannot be completely cured by surgery and frequently exhibit resistance to anticancer drugs (Martini et al., 1995; Hanahan and Weinberg, 2000; Jemal et al., 2010).