The High Pressure Processing (HPP) is a technique that can be applied to solid and liquid foods (usually 400–800 MPa; for short-term treatments 5–10 min) to provide microbiologically safe, nutritionally intact, and organoleptically high-quality The analysis of the changes in the volatile compounds of breast milk could serve as a general method to assess the effect of novel technologies, since modifications of these compounds could be the result of the development of multiple chemical reactions (oxidation, Maillard reaction, polymerization…) that takes place during milk processing.