Corticosteroids are frequently utilized for the
relief of progressive neurological symptoms.
Initially they provide a marked improvement;
however, this effi cacy is generally transient [ 18 ].
The dilemma often arises whether to further
increase the dose of corticosteroids for symptom
relief, which often results in a concomitant
increase in the side effects of steroids, which are
often burdensome in themselves. These adverse
effects include hyperphagia, weight gain, body
transformation, glucose intolerance, hypertension,
mood disturbance, gastrointestinal bleeding
and ulcers, and obstructive sleep apnea [ 18 ] .
Hyperphagia in itself can be of particular concern
in those children with swallowing disturbances,
as they are permanently hungry and are at risk of
choking
Corticosteroids are frequently utilized for therelief of progressive neurological symptoms.Initially they provide a marked improvement;however, this effi cacy is generally transient [ 18 ].The dilemma often arises whether to furtherincrease the dose of corticosteroids for symptomrelief, which often results in a concomitantincrease in the side effects of steroids, which areoften burdensome in themselves. These adverseeffects include hyperphagia, weight gain, bodytransformation, glucose intolerance, hypertension,mood disturbance, gastrointestinal bleedingand ulcers, and obstructive sleep apnea [ 18 ] .Hyperphagia in itself can be of particular concernin those children with swallowing disturbances,as they are permanently hungry and are at risk ofchoking
การแปล กรุณารอสักครู่..
