Given that older adults suffering from chronic disease are becoming more likely participate in Web 2.0 e-patient communication, it is surprising to note the paucity of formal evaluations examining use of Internet-mediated information and communication technologies (ICTs) among older adults. Specifically, there are no review articles that investigate the planning, implementation, and/or effectiveness of Web 2.0 self-management interventions among older adults with various chronic diseases. Consequently, few evidence-based recommendations exist regarding the development of Web 2.0 interventions for this vulnerable population [34]. A synthesis of the empirical evidence regarding the benefits and limitations of Web 2.0 interventions can enhance the transferability and translational potential of participatory technologies designed for healthy aging. Because of this emergent need, the primary objective of this study was to systematically review the planning, implementation, and overall effectiveness of Web 2.0 chronic disease self-management interventions delivered to older adults living with chronic disease.