Agaricus blazei Murrill (ABM) is a kind of mushroom which has long been used as a folk remedy for curing various diseases such as cancers, heart disease and diabetes in Brazil and Japan. Polysaccharide is one of the main bioactive constituents of Agaricus blazei Murrill with health functions (Delmanto et al., 2001; Mizuno, 1995).In order to realize all its promising applications, there is a great demand to supply the market with highquality Agaricus blazei Murrill polysaccharides (ABMP).