Check the tags for special washing instructions. Most clothes are machine washable, but always check the tag for further instructions. Some clothes might shrink if you use warm or hot water to wash. Some might be able to handle bleach and some might not. And some garments can't be washed in a machine, such as certain silks and delicates. Always check the label carefully.
Put aside clothes that are labeled as "hand wash only" or "dry clean only".
In most shirts, clothing care labels are located on the inside left side of the shirt or inside the neck area.
In most pants, clothing care labels are located on the inside of the back of the pants.