though a control procedure has been put in place,so that one set of equipment can be taken out of service for cleaning while full-scale operation is maintained in the duplicate equipment.
Even if equipment design has been directed towards the minimisation of biofouling, taking into account the factors that influence the accumulation of microorganisms on surfaces as discussed in Chapters 2 and 3, it is more than likely that some form of biofouling control will also be required.