The present study demonstrated a clear positive relationship
between plasma glucose concentration and birth weight and
a negative relationship between myo-inositol and D-chiroinositol
plasma concentrations on the one hand and birth
weight on the other hand in the naturally occurring pig
model of IUGR. Our results show that low birth weight
(LW) piglets have a significant higher concentration of both
inositols in plasma compared to larger littermates. As Myoinositol
and D-chiro-inositol have been coupled with glucose
intolerance and insulin resistance in adults, the present study
indicates that these metabolites could be novel biomarkers
for fetal programming