The findings of this study suggest four symptoms clusters were experienced by the patients with advanced cancer, including: “pain, sickness- behavior and psychological;” “anorexia-cachexia;” “gastro-intestinal and elimination;” and, “cutaneous and other.” Knowledge gained regarding symptom clusters, in patients with advanced cancer, possibly could assist healthcare providers in better understanding the pathophysiology of patients’ concomitant symptom experiences, which, in turn, could lead to successful management in relieving symptoms, reducing medication use and enhancing quality of life.