For evaluation of the solvent effects as one of the affectingparameters on the extraction of the HMPHA from extractsand tablets, chloroform, acetone, and methanol solventswith different strength and selectivity’s were selected.Then, two extraction methods consisted of maceration(24 hours) in combination with ultrasonic radiation (120minutes) or ultra-sonication alone were compared tocheck the effect of the procedure on the extraction (12).