In fungi, laccase is involved in a variety of cellular physiological events. This enzyme catalyzes the production of pigments, such as melanin in Lentinula edodes [11] and Cryptococcus neoformans [12], and cinnabarin in Pycnoporus mushrooms [13]. Melanins play important roles in the pathogenesis of C. neoformans in human [12], as well as in primordiation of L. edodes [11]. Cinnabarin, synthesized by Pycnoporus coccineus, exhibits antimicrobial activity [13]. Moreover, white rot fungi, such as Trametes versicolor and Pleurotus ostreatus, appear to produce laccases as a defense mechanism against environmental microorganisms [14].