Resistance to available antibiotics is increasing at a very
alarming stage globally21
. Efforts are urgently needed to
replace current available antibiotics. In this context, the
antibacterial activity of plants is continuously attracting
global attention22,23
.
Many plants have been used because of their
antimicrobial traits, which are due to compounds
synthesized in the secondary metabolism of the plant.
These products are known by their active substances, for
example, the phenolic compounds that are part of the
essential oils, as well as in flavonoid24,25
.
The results obtained from the chloroform phase showed a
significant and important antifungal effect against
Candida albicans. Conventionally, treatment for
candidiasis is usually done with the topical and oral
administration of antifungal azole and polyene, but has
been making frequent presence of such resistance to these
microorganisms drugs because thaeir heir inappropriate
use. Furthermore, these drugs can cause toxic effects and
considerable side, the decreases patient acceptance. Thus,
the use of medicinal plants as medicine traditional proves
to be quite attractive as an alternative therapy, requiring
studies science on the subject, which are still
insufficient26
.
In addition, the different behavior observed between
strains of the same species could be justified by the
existence of genetic variability among different strains27
.
This antifungal activity against Candida albicans of
CFPC has been observed in other studies with extracts of
plant species of the family Asteraceae28,29 and is showed
next to the results obtained with the ethanol extract of the
same plant3