In particular, testicular H1 histone, histone H2A.Bdb, and histone H2B type 1‑A (TH2B in mouse) are known to be involved in histone hyperacetylation and nucleosome destabilization prior the incorporation of transition proteins and protamines.69–72 However, histone roles should not be restricted to spermatogenic processes, as
an analogous hyperacetylation‑based paternal chromatin remodeling occurs after fertilization. Therefore, it would be logical to think that the sperm‑derived histone variants that remain in the zygotic nucleus could be also participating at that stage.17,56,70,71