Previous studies on hepatic cancer
showed that HBx was a general trans-activator and played a significant
role in intracellular signal transduction, viral replication,
cell cycle progression, cellular proliferation and apoptosis, protein
degradation and the genetic stability of liver cells [28,30,31]. In this
study, we evaluated HBV as a potential aggravating factor for PDAC
and identified the mechanisms through which HBx could influence
PDAC progression.