However, like all other computer-simulation analyses, ours was limited by reliance on multi-ple assumptions and data derived from multiple sources and study types. Because of limited evidence from clinical trials and the need to consider the complications of frailty, cognitive function, and an increased risk of side effects among patients 75 years of age or older, we limited our analyses to persons between the ages of 35 and 74 years. Because of our conservative approach, we did not capture disability or costs attributable to hypertensive heart disease, peripheral arterial disease, or end-stage renal disease and other noncardiovascular outcomes associated with hypertension. Therefore, we probably underestimated cost savings and QALY gains associated with hypertension treatment. We did not analyze effective diet and lifestyle interventions for lowering blood pressure in patients with hypertension, and we did not analyze the cost-effectiveness or other relative merits of specific antihypertensive medication classes or combinations. Finally, we did not analyze the potential synergistic benefits of simultaneous implementation of the 2014 hypertension guidelines and guidelines for controlling high cholesterol, diabetes, obesity, and other risk factors for cardiovascular disease, nor did we assess the value of hypertension treatment as part of an integrated guideline for managing all risk factors for cardiovascular disease on the basis of calculated global risk.