1. Wash your hands before and after. Try to empty your bowel and bladder just before use. 2. Remove protective cover from applicator. Attach applicator to tube. 3. Squeeze to fill the applicator with ointment. 4. Lubricate applicator well and then gently insert applicator into the rectum ½ inch. 5. Squeeze the tube so that ointment is applied inside rectum. 6. Thoroughly cleanse applicator after each use and replace protective cover. 7. Avoid having a bowel movement for one to three hours after inserting the ointment.