Combined with hot air drying of 60 °C, the effect of radio frequency heating at 6 kW, 27.12 MHz on the microbial, physico-chemical and sensory qualities of vacuum packaged Caixin was investigated. The high dielectric constant (ɛ′) and loss factor (ɛ″) of Caixin might have come from the salt addition before packaging, and the high loss factor (ɛ″) would have promoted the temperature increase during RF treatment. The RF treatment of 20 mm/20 min reduced the total colony number of Caixin by 3–4 log, while the physico-chemical and sensory properties were almost the same to those of the RF-untreated samples, which suggested that RF treatment at the present study has the potential to increase the food safety of vacuum packaged Caixin while not compromising of its product quality.