When livers
were perfusedwith different concentrations of homocysteine and adenosine,
the ratio of AdoMet/AdoHcy was decreased from this normal
level to 0.6 or 0.3, resulting in a 75% decrease and 99% decrease in PE
methylation, respectively. A similar conclusion was reached when the
AdoHcy hydrolase inhibitor 3-deazaadenosine, that elevates the concentration
of AdoHcy, was used in rat liver [37].