Among these active estradiols, 17β–estradiol is more studied and greater functions, since it potentially interacts with the estrogen receptor (ER) and the ER–17β–estradiol complex potentially regulates its target genes (Green et al. 1997). Since over three decades of women life are in a low estrogenic level, called menopausal state (50–80 year–old), the impact of prolong hypoestrogenic activity is now a critical health concern (Purohit and Reed 2002).