Merck & Company Incorporated’s origins start with Friedrich Merck in Darmstadt, Germany. He and Dr. Ernst Friedrich Schering began a small business selling pharmaceutical products in 1851. They passed on the company to Emanuel Merck, who began the process of creating a chemical-pharmaceutical factory that produced many different drugs and chemicals [16]. Doing so transformed the small pharmacy into a drug manufactory. Seeing the need to expand, Merck & Company opened its first operating building in the United States in 1891. The building was built in New York and was a subsidiary company of E.Merck (later to be known as Merck KGaA). In 1899, the Merck Manual of Diagnosis and Therapy was first published as a guide for physicians and pharmacists, making the company much more eminent in the United States. The manual became the best-selling medical textbook in history, and is still updated annually so that physicians can continue using it [16]. A more basic home-version has been created for the common person, and is now available in e-book, textbook and even mobile app version.