The present study is a part of a larger research project ‘National Guidelines for health promotion in health care – the challenge to apply scientific evidence in clinical practice’, which has the aim to study how new knowledge can be implemented and sustained in health care organizations. This larger project investigates the development and implementation of the National Guidelines for Lifestyle Interventions in Sweden. The implementation is studied at different levels of primary health care in two regions. The research project started in year 2010, and will end in 2013.