The.the prior evidence of similar associations
with other adverse pregnancy outcomes.
In a study of first trimester pregnancy
losses, HPV 16 DNA was isolated from
products of conception 60% after spontaneous
abortions compared with 20%
after elective termination.5 Moreover, a
case control study showed higher rate
of isolation of HPV type 6, 11, 16, or 18
from placentas of women with spontaneous
preterm labor before 37 weeks’
gestation compared with women with
labor after 37 weeks. The same study,
however, showed similar detection of
HR-HPV from placentas of women with
preterm severe preeclampsia and controls.6
The lack of association in this
latter study with preeclampsia is in
contrast with our study. As HPV is a
transient infection, it is theoretically
possible that infection early in pregnancy
could alter placental vascular architecture
and ultimately result in preeclampsia,
but then no longer be detectable
in the placenta at the time of delivery.
HPV infection may also affect uteroplacental
function even if it is limited to
the uterine decidua
The.the prior evidence of similar associationswith other adverse pregnancy outcomes.In a study of first trimester pregnancylosses, HPV 16 DNA was isolated fromproducts of conception 60% after spontaneousabortions compared with 20%after elective termination.5 Moreover, acase control study showed higher rateof isolation of HPV type 6, 11, 16, or 18from placentas of women with spontaneouspreterm labor before 37 weeks’gestation compared with women withlabor after 37 weeks. The same study,however, showed similar detection ofHR-HPV from placentas of women withpreterm severe preeclampsia and controls.6The lack of association in thislatter study with preeclampsia is incontrast with our study. As HPV is atransient infection, it is theoreticallypossible that infection early in pregnancycould alter placental vascular architectureand ultimately result in preeclampsia,but then no longer be detectablein the placenta at the time of delivery.HPV infection may also affect uteroplacentalfunction even if it is limited tothe uterine decidua
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