Several CE methods were also available in the recent literature for the determination and separation of antiretroviral drugs in serum samples using solid phase extraction procedures.19-22 Hyphenated CE-MS systems were also used.23 A few CE methods were reported for the determination and validation of antiretrovirals drugs in bulk drugs and pharmaceutical formulations.24,25 Sekar and Azhaguvel,25 separated and determined lamivudine and stavudine with the nevirapine (NNRTI) in pharmaceutical formulations by micellar electrokinetic capillary chromatographic (MEKC) method, all antiretroviral drugs were separated within 14 min using 10 mmol L-1 sodium tetraborate (pH 9.8), 100 mmol L-1 SDS and 15% 2-propanol as an organic modifier. The development of a simple CZE method when compared with MEKC method can supply a very useful alternative for routine analysis of pharmaceutical formulations.