The prognosis for complete recovery is good if the syndrome is recognized early and treated
aggressively with transfusion support. Patients with pain episodes that have unusually severe pain should be monitored closely for the development of acute multiorgan failure. Periodic
evaluation of hemoglobin, platelet counts, bilirubin, creatinine, and CPK especially on the thrid
or four day of the pain episode may increase early recognition. Alteration in mental status
requires prompt, complete evaluation and therapy.