The first paper to suggest a survival difference
was a meta-analysis of RCTs performed in cardiac surgery
comparing desflurane or sevoflurane with TIVA.Similar
results were suggested by a meta-analysis of RCTs comparing
isoflurane with TIVA when only high-quality studies performed
in cardiac surgerywere considered. An RCTreported large 1 yr
mortality differences between sevoflurane, desflurane, and
TIVA in CABG surgery patients, even if the high mortality rates
observed in the TIVA group could be attributed, at least in part,
to chance effects.